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华西医学  2015 

β-catenin和Galectin-3在宫颈癌组织中的 表达及其临床病理学意义

DOI: 10.7507/1002-0179.20150416, PP. 1452-1456

Keywords: β-catenin,Galectin-3,宫颈癌,浸润,转移

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Abstract:

目的?探讨β-catenin和Galectin-3蛋白在宫颈癌的表达及临床病理学意义。方法?收集2010年1月-2013年6月间手术切除经病理证实为宫颈癌标本83例。采用免疫组织化学法检测83例宫颈癌组织、45例宫颈上皮内瘤变(CIN)及25例正常宫颈中β-catenin和Galectin-3的表达。结果?①在宫颈癌组织中β-catenin和Galectin-3阳性表达率分别为74.70%、81.93%,均显著高于CINⅠ、CINⅡ和正常宫颈组织(P<0.05);但在CINⅢ中的表达与在宫颈癌中的表达差异无统计学意义(P>0.05),三者合并后与宫颈癌比较差异有统计学意义(P<0.05)。②β-catenin蛋白的表达与患者年龄、肿瘤大小及病理类型无关(P>0.05),与组织学分级、国际妇产科联盟(FIGO)分期及淋巴结转移有关(P<0.05);Galectin-3蛋白的表达与患者年龄、FIGO分期、肿瘤大小及病理类型无关(P>0.05),与组织学分级及淋巴结转移有关(P<0.05)。③β-catenin和Galectin-3蛋白表达呈正相关(r=0.327,P=0.002)。结论?宫颈癌组织中Galectin-3的高表达及β-catenin的高表达与宫颈癌的浸润、转移有关,并可能成为判断宫颈癌组织转移及预后的指标之一。

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