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华西医学  2010 

Akt与肿瘤关系的研究进展

, PP. 2291-2294

Keywords: Akt,肿瘤,研究

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Abstract:

【】丝氨酸/苏氨酸蛋白激酶B(proteinkinaseB,PKB/Akt)作为一种癌基因,通过磷酸化其下游分子,介导或参与细胞周期的调节、细胞生长、凋亡、增殖等多种生物学活性,从而参与肿瘤的发生、发展。这使得Akt可能成为肿瘤基因治疗、抗肿瘤药物开发新的作用靶点。现就Akt的结构、活化和调节及在肿瘤中的作用予以综述。

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