甲氨蝶呤小剂量分次给药联合米非司酮治疗早期异位妊娠的临床研究

【】　目的　探讨甲氨蝶呤(MTX)联合米非司酮治疗早期异位妊娠(EP)的临床效果。　方法　收集2006年2月-2010年2月收治的早期未破裂型EP患者126例，随机分为MTX联合米非司酮组62例，单独应用MTX组64例，MTX治疗采用小剂量分次肌肉注射给药进行。　结果　126例患者中，MTX联合米非司酮组和单独应用MTX治疗组的成功率为分别为88%和65%，两组差异有统计学意义(P<0.05)。　结论　MTX小剂量分次给药联合米非司酮治疗早期未破裂型EP效果优于MTX的单独使用。？【Abstract】　Objective　Toobservethetherapeuticeffectofmethotrexate(MTX)combinedwithmifepristoneonearlyectopicpregnancy.　Methods　Atotalof126patientswithearlyectopicpregnancydiagnosedfromFebruary2006toFebrary2010wererandomlydividedintotwogroups.In126patients,62treatedwithMTXcombinedwithmifepristonewereinthetreatmentgroup,and64treatedindependentlywithMTXwereinthecontrolgroup.MTXwasadministratedatalowdoseinseveraltimes.　Results　In126patients,thesuccessratioofthetreatmentwas88%intreatmentgroupgroupsand65%inthecontrolgroup;thedifferencebetweenthetwogroupswassignificant(P<0.05).　Conclusion　Low-doseMTXinseparatetimescombinedwithmifepristoniseffectiveontheearlyectopicpregnancy,andthetherapeuticeffectofthecombinedadministrationofMTXandmifepristonisbetterthanthatofthesingleadministrationwithMTX.