左氧氟沙星联合阿奇霉素治疗老年难治性呼吸道感染的临床分析

【】　目的　探讨左氧氟沙星联合阿奇霉素治疗老年难治性呼吸道感染的疗效及安全性。　方法　选择2005年2月-2010年9月收治的高龄难治性呼吸道细菌感染患者68例，随机分为治疗组和对照组。治疗组34例，给予左氧氟沙星联合阿奇霉素；对照组34例，给予左氧氟沙星，两组总疗程皆为15d。观察两组患者的临床疗效、细菌清除率和不良反应。　结果　治疗组的总有效率为64.71%，对照组总有效率为32.35%，两组差异有统计学意义（P0.05）。结论　左氧氟沙星联合阿奇霉素治疗老年难治性呼吸道感染疗效高，能有效清除细菌，不良反应较少，值得临床推广应用。？【Abstract】　Objective　Toevaluatetheefficacyandsafetyoflevofloxacincombinedwithazithromycinonrefractoryrespiratoryinfectionsinelderpatients.　Methods　Atotalof68elderpatientswithrefractoryrespiratoryinfectionsinourhospitalfromFebruary2005toSeptember2010wererandomlydividedintotwogroupstreatmentgroup(n=34)andcontrolgroup(n=34).Thepatientsintreatmentgroupweretreatedwithlevofloxacincombinedwithazithromycin;whilethepatientsinthecontrolgroupweretreatedwithlevofloxacinalone.Thetotaltreatmentperiodsofbothgroupswere15days.Thetherapeuticefficacy,eradicationrateofpathogensandtherateofaelversereactionswereobserved.　Results　Thetherapeuticeffectratewas64.71%inthetreatmentgroupand32.35%inthecontrolgroup,andthedifferencebetweenthetwogroupswasstatisticallysignificant(P0.05).　Conclusion　LevofloxacincombinedwithAzithromyciniseffectiveonrefractoryrespiratorytractinfectioninelderpatients,whichcaneffectivelyremovethebacteriawithfewadversereaction.