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华西医学  2010 

原发性肠道非霍奇金淋巴瘤穿孔的临床预后分析

, PP. 1960-1963

Keywords: 肠肿瘤,淋巴瘤,穿孔,预后

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Abstract:

【】 目的 对原发性肠道非霍奇金淋巴瘤穿孔患者的临床及病理特征、诊治、预后进行探讨。 方法 回顾性分析1999年1月-2008年12月诊治的17例原发性肠道非霍奇金淋巴瘤穿孔患者的临床资料。 结果 B细胞型9例,T细胞型8例。17例原发肠道非霍奇金淋巴瘤穿孔患者的穿孔部位大肠7例,小肠7例,回盲部3例。所有患者均行手术治疗。除2例穿孔前行化疗的患者以外,其余患者术前均未明确诊断。有14例获得随访结果,6例术后3个月内死亡,术后接受化疗者7例,1、2、3年生存率分别为41.2%、23.6%、11.7%,仅1例生存期超过5年。 结论 原发性肠道非霍奇金淋巴瘤穿孔术前诊断困难,预后极差。?【Abstract】 Objective Toanalyzetheclinicalfeatures,diagnosis,therapyandprognosisofprimaryintestinalnon-hodgkin′slymphomaperforation. Methods Theclinicaldataof17patientswiththeprimaryintestinalnon-Hodgkin′slymphomaperforationfromJanuary1999toDecember2008wereretrospectivelyanalyzed. Results NinepatientshadintestinalB-celllymphoma,andeighthadintestinalT-celllymphoma.Thesitesofperforationwereasfollowscolonandrectumin7(41.2%),ileumandjejunumin7(41.2%),andileocecaljunctionin3(17.6%).Allpatientshadundergonetheoperations.ThediseasewasnotdiagnosedbeforetheoperationinallofthepatientsexceptfortheTwopatientshadahistoryofsystemicchemotherapybeforeperforation.Atotalof14patientswerefollowedup,inwhomsixdiedwithinthreemonthsaftertheoperation;thesurvivalrate1,2,and3yearsaftertheoperationwas41.2%,23.6%,and11.7%,respectivelyinsevenpatientswhohadundergonethesystemicchemotherapybeforetheoperation;onepatientslivedmorethan5years. Conclusion Thediagnosisofprimarycolonicmalignantlymphomaperforationisdifficult;theprognosisismiserable.

References

[1]   d′Amore F, Brincker H, Gronbaek K, et al. Non-Hodgkin′s lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathogic presentation features, and prognosis. Danish lymphoma Study Group[J]. J Clin Oncol 1994, 12(8): 1673-1684.
[2]   Otter R, Bieger R, Kluin PM, et al. Primary gastrointestinal non-Hodgkin′s lymphoma in a population-based registry[J]. Br J Cancer, 1989, 60(5): 745-755.
[3]   Domizio P, Owen R, Shepherd N, et al. Primary lymphoma of the small intestine: a clinicopathological study of 119 cases[J]. AM J Surg Pathol, 1993, 17(5): 429-442.
[4]   Amromin GD, Solomon RD. Necrotizing enteropaty: a complication of treated leukemia or lymphoma patients[J]. JAMA, 1962, 182(1): 23-29.
[5]   Daum S, Ullrich R, Heise W, et al. Intestinal non-Hodgkin′s lymphoma: a multicenter prospective clinical study from the german study group on intestinal non-Hodgkin′s lymphoma[J]. J ClinOncol, 2003, 21(14): 2740-2746.
[6]   Yin L, Chen CQ, Peng CH, et al. Primary small-bowel non-Hodgkin′s lymphoma: a study of clinical features, pathology, management and prognosis[J]. J Int Med Res, 2007, 35(3): 406-415.
[7]   Peter K, Francisco del Valle, Wolfgang E, et al. Primary gastrointestinal non-Hodgkin′s lymphoma: Ⅰ. anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German multicenter study GIT NHL 01/92[J]. J Clin Oncol, 2001, 19(18): 3861-3873.
[8]   Freeman HJ. Free perforation due to intestinal lymphoma in biopsy-defined or suspected celiac disease[J]. J Clin Gastroenterol, 2003, 37(4): 299-302.
[9]   Jamhbuklar MI, Joshi MA, Balsarkar D, et al. Perforation of jejunal on-Hodgkin′s lymphoma[J]. India J Gastroneterol, 2004, 23(3): 110-111.
[10]   Kim HS, Lee DK, Bail SK, et al. Primary CD56+T/NK cell lymphoma of the colon[J]. J Gastroenterol, 2002, 37(11): 939-946.
[11]   Ara C, Coban S, Kayaalp C, et al. Spontaneous intestinal perforation due to non-Hodgkin′s lymphoma: evaluation of eight cases[J]. Dig Dis Sci, 2007, 52(8): 1752-1756.
[12]   Musshoff K, Schmidt-follmer H. Prognosis of non-Hodgkin′s lymphoma with special emphasis on the staging classification[J]. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol, 1975, 83(4): 323-340.
[13]   Daum S, Ullrich R, Heise W, et al. Intestinal non-Hodgkin′s lymphoma: a multicenter prospective clinical study from the German Study Group on lntestinal non-Hodgkin′s lymphoma[J]. J Clin Oncol, 2003, 21(14): 2740-2746.
[14]   Ibrahim EM, Ezzat AA, EI-Weshi AN, et al. Primary intestinal diffuse large B-cell non-Hodgkin′s lymphoma: clinical features, management, and prognosis of 66 patients[J]. Ann Oncol, 2001, 12(1): 53-58.
[15]   Aydin I, Baskent A, Celik G, et al. A case of primary intestinal lymphoma associtated with intestinal perforation[J]. Ulus Travma Derg, 2001, 7(1): 74-76.
[16]   Yokota T, Yamada Y, Murakami Y, et al. Abdominal crisis caused by perforation of ileal lymphoma[J]. Am J Emerg Med, 2002, 20(2): 136-137.
[17]   Hata S, Pietsch J, Shanka S. Intestinal complications in children undergoing chemotherapy for mediastinal non-Hodgkin′s lymphoma[J]. Pediatr Hematol Oncol, 2004, 21(8): 707-710.
[18]   Meyers PA, Potter VP, Wollner N, et al. Bowel perforation during initial treatment for childhood non-Hodgkin′s lymphoma[J]. Cancer, 1985, 56(2): 259-261.
[19]   Nakamura S, Matsumoto T, Takeshita M, et al. A clinicopathologic study of primary small intestine lymphoma: prognostic significance of mucosa-associated lymphoid tissue-derived lymphoma[J]. Cancer, 2000, 88(2): 286-294.
[20]   Amer MH, el-Akkad S. Gastrointestinal lymphoma in adults: clinical features and management of 300 cases[J]. Gastroenterology, 1994, 106(4): 846-858.

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