门冬氨酸鸟氨酸治疗肝性脑病的临床研究

【】目的应用门冬氨酸鸟氨酸对肝性脑病的临床疗效及安全性进行观察。方法2000年4月-2009年11月，将60例肝硬化肝性脑病患者分为对照组和治疗组，对照组给予常规精氨酸治疗，治疗组在对照组基础上加门冬氨酸鸟氨酸10g/d，静脉滴注，连续7d。观察治疗前后神志变化、血清氨基转移酶(ALT、AST)、血清白蛋白(ALB)等指标变化。结果治疗组经门冬氨酸鸟氨酸治疗后神志改变、ALT、AST明显优于治疗前（P<0.05）。结论门冬氨酸鸟氨酸治疗肝性脑病疗效确切，且对肝功能有改善作用，副反应小。？【Abstract】ObjectiveToevaluatetheclinicalefficacyandsafetyofL-ornithine-L-aspartatetreatingthepatientswithhepaticencephalopathy.MethodsSixtypatientswithhepaticencephalopathyfromApril2000toNovember2009wererandomlydividedintotreatmentgroupandcontrolgroupwith30patientsineach.Thepatientsinthecontrolgroupweretreatedwiththeroutinetherapyofarginine,whiletheonesinthetreatmentgroupweretreatedwithL-ornithine-L-aspartatebesidestheroutinetherapyforoneweekinjection(10.0gdissolvedin5%glucose250mLbyintravenousinfusiononcedaily),theliverfunctionandmindchangewereobservedinallpatientsattheonsetandoneweekaftertreatmentrespectively.ResultsOneweekafterthetreatment,theliverfunction(ALT,AST)andmindchangeofpatientsdifferedstatisticallysignificantlyfromthatbeforethetreatment(P<0.05).ConclusionL-ornithine-L-aspartateiseffectiveforthepatientswithminimalhepaticencephalopathy,whichcouldimprovetheliverfunctionwithlittlesideeffect.