? Seltzer HS, Allen EW, Herron AL Jr, et al. Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus[J]. J Clin Invest, 1967, 46(3): 323-335.
[2]
? Lupi R, Dotta F, Marselli L, et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated[J]. Diabetes, 2002, 51(5): 1437-1442.
[3]
? Lameloise N, Muzzin P, Prentki M, et al. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion[J]Diabetes, 2001, 50(4): 803-809.?
[4]
? Gremlich S, Bonny C, Waeber G, et al. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels[J]. J Biol Chem, 1997, 272(48): 30261-30269.
[5]
? Riedel MJ, Boora P, Steckley D, et al. Kir6. 2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes[J]Diabetes, 2003, 52(10): 2630-2635.
[6]
? Poitout V, Robertson RP. Minireview: Secondary beta-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity[J]. Endocrinology, 2002, 143(2): 339-342.
[7]
? Cnop M, Hannaert JC, Hoorens A, et al. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation[J]. Diabetes, 2001, 50(8): 1771-1777.