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华西医学  2010 

实时荧光显像在胶质瘤术中应用的研究进展

, PP. 1385-1387

Keywords: δ-氨基-γ-酮戊酸,荧光素钠,纳米荧光探针,靛氰绿,多光子,胶质瘤术

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Abstract:

【】胶质瘤是中枢神经系统发病率最高的恶性肿瘤,目前的治疗方法是以手术为主、放化疗为辅的分级分型个体化综合治疗,其中手术为最快速和有效去除肿瘤组织的手段。由于肿瘤常呈浸润性生长,术中肿瘤边界显示不清,要达到术中全切非常困难。提高肿瘤边界判断的准确性,以助于术者最大限度地切除肿瘤,便成为改善患者预后的主要方法。术中实时荧光显像技术为近年来蓬勃发展的判断肿瘤边界的新技术。目前国际上荧光显像方法主要有δ-氨基-γ-酮戊酸、荧光素钠、纳米荧光探针、靛氰绿、多光子激发荧光等引导的荧光显像法,前两者相对较成熟而后三者仍处于研究之中。本文就术中实时荧光显像在胶质瘤术中应用进行阐述。

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