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华西医学  2011 

环氧化酶-2抑制剂致心血管系统疾病的作用机制

, PP. 1581-1584

Keywords: 环氧化酶-2抑制剂,心脏作用

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Abstract:

【】 环氧化酶(cycloxygenase,COX)有两种异构酶,COX-1对机体起生理性保护作用;COX-2参与炎症等病理作用调节。非甾体类药物抗炎镇痛作用源于对COX-2的抑制,而胃肠道等不良反应的发生则与COX-1被抑制密切相关。近年研究发现COX-2抑制剂有可能增加心血管病发病危险,现综述COX-2抑制剂导致心脏疾病的作用机制以及目前COX-2抑制剂临床应用进展。

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