盐酸卡替洛尔治疗原发性开角型青光眼前后的眼压脉动幅度观察

【】　目的　了解原发性开角型青光眼患者用2%盐酸卡替洛尔滴眼液后的眼压及眼脉动幅度变化特征。　方法　选取2009年1－12月确诊为原发性开角型青光眼患者19例32只眼。给予2%盐酸卡替洛尔滴眼液点眼1周，2次/d。用动态轮廓眼压计测量患者用药前后的眼压、眼脉动幅度，同时测量患者的血压及心率。比较用药前后眼压及眼脉动幅度的变化，并用SPSS14.0统计学软件对用药前后的眼压及眼脉动幅度数据进行配对t检验及Pearson相关性分析。　结果　患者用药前后眼压分别为（22.76±4.29）、（17.79±2.93）mmHg（1mmHg=0.133kPa），眼脉动幅度分别为（3.47±1.00）、（2.63±0.86）mmHg。患者的眼压及眼脉动幅度用药后较用药前明显降低，差异有统计学意义（P<0.01），用药前后的眼压与眼脉动幅度之间存在正相关关系（r=0.444，0.364；P=0.011，P=0.040）。眼压及眼脉动幅度与患者的血压及心率均无相关性。　结论　原发性开角型青光眼患者用2%盐酸卡替洛尔滴眼液后眼压及眼脉动幅度均有显著降低，眼压与眼脉动幅度有正相关性。眼压及眼脉动幅度与血压及心率无相关关系。【Abstract】　Objective　Toinvestigatethevariationsofintraocularpressure(IOP)andocularpulseamplitude(OPA)inpatientswithprimaryopen-angleglaucomaafter2%carteololhydrochloridewasapplied.　Methods　Thirty-twoeyesof19patientswithprimaryopen-angleglaucomadiagnosedbetweenJanuaryandDecember2009werechosentobethestudysubjects.Thepatientsreceived2%cartelolhydrochlorideeyedropstwiceadayforoneweek.IOPandOPAbeforeandafterusingcartelolweremeasuredbydynamiccontourtonometry(DCT).Bloodpressureandheartrateweredetectedatthesametime.ThevariationsofIOPandOPAwereanalyzedbySPSS14.0.ttestandPearsoncorrelationanalysiswereapplied.　Results　ThemeanIOPandOPAbeforeandafterusingcartelolwererespectively(22.76±4.29)mmHg(1mmHg=0.133kPa)vs.(17.79±2.93)mmHg,and(3.47±1.00)mmHgvs.(2.63±0.86)mmHg.Bothofthemdecreasedsignificantlyaftertheuseofcartelol(P＜0.01).OPAwasobviouslycorrelatedwithIOPbothbeforeandafterusingcartelol(r=0.444,0.364;P=0.011,0.040).OPAandIOPhadnocorrelationwithbloodpressureandheartrate.　Conclusions　OPAandIOPdecreasessignifficantlyaftertheuseof2%carteololhydrochloride.OPAissignifficantlycorrelatedwithIOP.OPAandIOPhavenocorrelationwithbloodpressureandheartrate.