IgA肾病肾血管病变危险因素的非条件logistic回归分析

【】　目的　探讨IgA肾病肾血管病变的危险因素。　方法　回顾性分析2000年1月－2009年6月间经肾活检确诊的175例IgA肾病患者资料，其中有肾血管病变者93例，无肾血管病变者82例，进行对照研究。采用多因素非条件logistic回归模型分析影响IgA肾病肾血管病变的危险因素。　结果　高血压OR=11.593，P=0.001，95%CI（2.800，47.991）、24h尿蛋白定量OR=1.754，P=0.001，95%CI（1.270，2.424）、血肌酐OR=1.005，P=0.001，95%CI（1.002，1.008）、肾小球硬化OR=8.341，P=0.000，95%CI（2.716，25.610）、肾间质纤维化OR=4.880，P=0.014，95%CI（1.385，17.199）对IgA肾病肾血管病变的影响有统计学意义。　结论　高血压、24h尿蛋白定量、血肌酐、肾小球硬化和肾间质纤维化可能是影响IgA肾病肾血管病变的独立危险因素。积极控制以上危险因素对延缓IgA肾病病变的进展具有重要意义。【Abstract】　Objective　ToexploretheriskfactorsforrenalvascularlesionsinpatientswithimmunoglobulinA(IgA)nephropathy.　Methods　Weretrospectivelyanalyzedtheclinicaldataof175IgAnephropathypatientsdiagnosedthroughrenalbiopsyfromJanuary2000toJune2009.Amongthem,therewere98casesofrenalvascularlesionsand82caseswithoutrenalvascularlesion.Controlledstudybetweenthetwogroupsofpatientswerecarriedout.AmultivariateunconditionallogisticregressionmodelwasemployedtoanalyzetheriskfactorsforrenalvascularlesionsinIgAnephropathypatients.　Results　ThefollowingfactorshadsignificantcorrelationswithrenalvascularlesionsinIgAnephropathypatientshypertensionOR=11.593,P=0.001,95%CI(2.800,47.991),24-hoururineproteinlevelOR=1.754,P=0.001,95%CI(1.270,2.424),serumcreatinineOR=1.005,P=0.001,95%CI(1.002,1.008),glomerulosclerosisOR=8.341,P=0.000,95%CI(2.716,25.610),andrenalinterstitialfibrosisOR=4.880,P=0.014,95%CI(1.385,17.199).　Conclusion　Hypertension,24-hoururineprotein,serumcreatinine,glomerulosclerosisandrenalinterstitialfibrosiswereriskfactorsforrenalvascularlesionsinIgAnephropathypatients.Itwillbeverysignificanttoactivelycontrolalltheaboveriskfactorstopreventoccurrenceofrenalvascularlesions.