海洋肽对恶性肿瘤化学治疗患者营养状况及免疫功能的影响

【】　目的　探讨海洋肽对恶性肿瘤化学治疗（简称化疗）患者营养状况和免疫功能的影响。　方法　依照纳入排除标准选取2010年3－11月66例恶性肿瘤化疗患者，随机分为试验组和对照组，每组各33例。在正常饮食基础上，试验组和对照组分别服用海洋肽制剂和乳清蛋白制剂21d，进行肝肾功能、营养状况及免疫指标的测定。　结果　干预前后两组肝肾功及血脂指标差异无统计学意义（P>0.05），且均在正常范围内。试验组干预后体质指数（bodymassindex，BMI）、上臂围、上臂肌围、总蛋白、白蛋白、球蛋白、前白蛋白（prealbumin，PA）、转铁蛋白较干预前升高有统计学意义（P0.05）；对照组干预前后各指标差异均无统计学意义（P>0.05）；试验组BMI、PA的前后差值较对照组高（P0.05）。两组在干预前后组内比较及组间免疫指标差值比较，差异均无统计学意义（P>0.05）。　结论　海洋肽作为部分氮源应用于恶性肿瘤化疗患者，对患者的内脏蛋白、人体测量等均有一定的营养改善作用，但对免疫功能的影响不明显，尚待进一步研究。【Abstract】　Objective　Toinvestigatetheeffectsofmarinepeptideonthenutritionalstatusandimmunefunctioninmalignanttumorpatientsundergoingchemotherapy.　Methods　Accordingtoinclusiveandexclusivecriteria,66malignanttumorpatientsundergoingchemotherapyfromMarch2010toNovember2010wererandomizedintostudygroupandcontrolgroupwith33patientsineachgroup.Thepatientsinthestudygroupweregivenmarinecollagenpeptidewheyproteinwhilethoseinthecontrolgroupweregivenwheyproteinfor21days.Liverandkidneyfunction,nutritionalstatusandimmunefunctionwereobservedbeforeandafterintervention.　Results　Liver,kidneyfunctionandbloodlipidsofallthepatientswerewithinnormalrange,andwerenotsignificantlydifferentbetweenthetwogroupsbeforeandafterintervention(P＞0.05).Afterintervention,bodymassindex(BMI),armcircumference,armmusclecircumference,totalprotein,albumin,globulin,prealbumin(PA),transferringproteinofthestudygroupweresignificantlyincreased(P＜0.05),buthemoglobinandtricepsskinfoldthicknesshadnosignificantchanges(P＞0.05).Therewasnosignificantdifferenceoftheaboveparametersinthecontrolgroupbeforeandafterintervention(P＞0.05).ThemagnitudeofchangeofPAandBMIbeforeandafterinterventionwerehigherinthestudygroupthanthoseinthecontrolgroup(P＜0.05),whilethemagnitudeofchangeofotherparametersbeforeandafterinterventionshowednosignificantdifferencebetweenthetwogroups(P＞0.05).Theimmunefunctionshowednosignificantchangeinbothgroupsbeforeandafterintervention(P＞0.05),anditwasalsonotsignificantlydifferentbetweenthetwogroups.　Conclusion　Aspartofdietarynitrogensources,marinepeptidecansignificantlyimprovenutritionalstatus,includingvisceralproteinandanthropometryinmalignanttumorpatientsundergoingchemotherapy,butithasnosignificanteffectonimmunefunction,whichshouldbefurtherstudiedindetail.