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华西医学  2011 

乳腺浸润性导管癌组织中表皮钙黏蛋白的表达及其意义

, PP. 983-985

Keywords: 乳腺浸润性导管癌,表皮钙黏蛋白,免疫组织化学,表达

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Abstract:

【】 目的 探讨乳腺浸润性导管癌中表皮钙黏蛋白(E-cadherin,E-cad)的表达及其意义。 方法 选取2005年1月-2009年12月的组织病理切块,用免疫组织化学EnVision二步法检测63例乳腺浸润性导管癌(invasiveductalcarcinoma,IDC)组织中E-cad的表达情况,设为IDC组;另检测15例乳腺纤维腺瘤及15例乳腺小叶增生症乳腺组织中E-cad的表达情况,设为对照组;比较两组的E-cad表达。 结果 E-cad在IDC组及对照组中表达阳性率分别为58.7%、80.0%;两组间差异有统计学意义(P0.05);肿块直径0.05);组织学分级为Ⅰ+Ⅱ级和Ⅲ级组的E-cad阳性表达率分别是76.3%、32.0%,两组间差异有统计学意义(P0.05).ThepositiveratesofE-cadproteinexpressionfortumorswithadiameter0.05).ThepositiveratesofE-cadproteinexpressionforclassⅠ+ⅡtumorsandclassⅢtumorswererespectively76.3%and32.0%withasignificantdifference(P<0.05).ThepositiveratesofE-cadproteinexpressionforpatientswithoutandwithaxillarylymphnodemetastasiswererespectively78.3%and47.5%withasignificantdifference(P<0.05). Conclusions TheexpressionofE-cadiscorrelatedwithhistologicalclassificationandlymphnodemetastasisandwasnotrelatedtotumorsizeandageofthepatients.TheexpressionofE-cadishigherinIDCpatientswithoutlymphnodemetastasisthanthatinIDCpatientswithlymphnodemetastasis,whichindicatesthatE-cadisanimportantindexforlymphnodemetastasisofIDC.

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