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华西医学  2011 

万珂提高多发性骨髓瘤干细胞采集的临床研究

, PP. 521-523

Keywords: 多发性骨髓瘤,万珂,化学疗法,造血干细胞

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Abstract:

【】 目的 研究以万珂为主化学疗法方案提高多发性骨髓瘤初发患者自体外周血造血干细胞采集的作用。 方法 回顾性分析2006年1月-2010年11月4例初发多发性骨髓瘤患者在万珂治疗后自体外周血造血干细胞采集的临床资料。疗效判定依据国际骨髓瘤工作组2006年疗效判断标准。 结果 经过万珂为主化学疗法方案治疗3~6个疗程(平均4个疗程)后,3例获得CR及以上疗效,均顺利实施了外周血造血干细胞采集;3例采集次数仅1次,1例为2次;平均获得CD34+细胞8.43×106/kg,完全达到采集要求。 结论 万珂为主化学疗法方案起效快、疗效好,可以提高初发多发性骨髓瘤患者的干细胞采集率。【Abstract】 Objective Toexploretheimprovementofautologousstemcellscollectioninpatientswithnewly-diagnosedmultiplemyelomaafterVelcade-basedchemotherapy. Methods TheclinicaldataoffourpatientswithmultiplemyelomawhounderwentVelcade-basedchemotherapybetweenJanuary2006andNovember2010wereretrospectivelyanalyzed.Thetherapeuticeffectwasobserved. Results After3-6courses(mean4courses)ofVelcade-basedchemotherapy,3patientsobtainedcompleteremission(CR)andaboveresponse,andthesufficientperipheralbloodhematopoieticstemcellswerecollectedsuccessfully.Theperipheralbloodhematopoieticstemcellswerecollectedonceinthreepatientsandtwiceinonepatient.Sufficientnumberofhematopoieticstemcells(meanCD34positive-cell8.43×106/kg)werecollectedwhichfullymetthecollectionrequirements. Conclusion Velcade-basedchemotherapyhasadvantagesoffastactionandgoodtherapeuticeffect,whichcanimprovethecollectionofautologousstemcellsinpatientswithnewly-diagnosedmultiplemyeloma.

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