实验性脑梗死对大鼠心率变异性的影响

【】　目的　探讨急性脑梗死对心脏自主神经活性的影响。　方法　Wistar大鼠32只随机分为正常组、假手术组和脑梗死组，脑梗死组用线栓法行右侧大脑中动脉阻塞。脑梗死组和假手术组于术前及术后24h作心率变异性（HRV）检测，同时检测正常组HRV，将3组的HRV指标进行比较。实验终点取各组心肌组织检测儿茶酚胺和神经肽Y（NPY），进行组间比较。　结果　术后24h脑梗死组和正常组、假手术组相比，窦性心搏间期标准差、均方根，总功率谱、高频功率谱（HF）、低频功率谱（LF）降低，差异有统计学意义。3组比较LF/HF和分数维无明显差异。脑梗死组心肌组织去甲肾上腺素（NA）和NPY高于正常组和假手术组。　结论　脑梗死引起心脏自主神经总活性降低、自主神经功能受损，自主神经末梢去甲肾上腺素和NPY的异常分泌可能是重要的原因。【Abstract】　Objective　Toinvestigatetheeffectofacutecerebralinfarctiononcardiacautonomicnervousactivity.　Methods　Atotalof32Wistarratsweredividedintonormalgroup,shamoperationgroupandinfarctiongroupbyrandom.ExperimentalcerebralinfarctioninWistarratswasinducedbyintraluminalocclusionofmiddlecerebralartery.About24hoursaftertheocclusionor24hoursaftershamoperation,theheartratevariability(HRV)sequencesweremeasured,andtheHRVvaluesinthethreegroupswerecompared.Thelevelsofcatecholamineandneuropeptide(NPY)inmyocardiumweremeasured.　Results　Atthe24thhouraftertheocclusion,thestandarddeviationandrootmeansquarestandarddeviationofR-Rinterval,thetotalpower,highfrequency(HF)andlowfrequency(LF)ininfarctiongroupwerelowerthanthoseinnormalandshamoperationgroup.LF/HFandfractaldimensiondidnotdiffermuchamongthethreegroups.ThelevelsofnoradrenalineandNPYinmyocardiumininfarctiongroupwerehigherthanthoseintheothergroups.　Conclusion　Itissuggestedthatacutecerebralinfarctionmaycausethedecreaseofautonomicnervousactivityanddamageoftheautonomicnervousfunction;theabnormalsecretionofnoradrenalininautonomicnerveendingandNPYmaybetheimportantreasons.