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华西医学  2011 

肾癌基因治疗研究进展

, PP. 471-475

Keywords: 肾癌,基因治疗,研究进展

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Abstract:

【】 肾癌是泌尿系统最常见的恶性肿瘤之一,近年来有不断上升的趋势。将近一半的肾癌患者首次就诊时已属晚期或有远处转移,约50%的患者术后复发或转移。肾癌的治疗目前仍以手术为主,放射治疗及化学疗法效果均不佳,生物治疗逐渐展露优势,其中,随着新的肾癌相关基因的发现,基因治疗已成为近年来肾癌研究的热点。应用于肾癌的基因治疗方法目前有干扰增殖基因表达、修复抑癌基因、控制凋亡调控基因的表达、转基因免疫产物抑癌疗法、自杀基因疗法及基因治疗联合化学疗法等等。这些方法虽然目前发展不甚成熟,但却为肾癌生物治疗提供了新的契机。

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