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华西医学  2011 

深部真菌感染的耐药机制研究进展

, PP. 142-145

Keywords: 真菌,耐药机制,真菌外排泵,靶酶CYP51,FKS1基因

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Abstract:

【】随着深部真菌感染日益增加及抗真菌药物的广泛应用,深部真菌耐药现象也日益突出。近十年以来,虽有较多新型抗真菌感染药物相继研发并应用于临床,但国内外已有较多对其耐药的病案报道。真菌面对唑类等强大的抗真菌药物也不断产生着严重的耐药性,并迅速使一些院内真菌感染陷入了无药可选的境地。因此,研究真菌的耐药机制并寻找新的抗真菌药物已成当务之急。现就按照抗真菌药物分类,对近年来国内外深部真菌感染的耐药机制的研究进展进行综述,以明确深部真菌耐药发生的诱因、机制,为指导临床合理使用抗真菌药物;尽可能减少深部真菌耐药的发生及研究新一代抗真菌药物提供参考。

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