|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
2型糖尿病胰岛素抵抗与糖尿病性心功能不全的观察
, PP. 44-46
Keywords: 胰岛素抵抗,糖尿病性心功能不全,超声心动电描技术,多普勒
Abstract:
【】 目的 探讨2型糖尿病（T2DM）胰岛素抵抗导致糖尿病性心功能不全的临床表现特点及相关激素的改变。 方法 2008年1-4月对T2DM患者35例（胰岛素抵抗指数HOMA-IR0.05）。ANP、BNP及DT值在A1、A2组均较B组增高（P0.05）。E/A、e/a和S/D在A1、A2组均较B组降低（P0.05）。A2组患者LVEF较A1、B组均明显降低（P0.05）。 结论 随着胰岛素抵抗加重，心肌舒张顺应性较差和收缩力下降，伴随相关激素（心脏利钠肽）分泌增加，最终产生心功能不全的临床表现、体征及多普勒超声心动图表现。【Abstract】 Objective Toinvestigatetheclinicalfeaturesandrelatedhormonechangesofdiabeticcardiacinsufficiencyleadedbyinsulinresistanceintype2diabetesmellitus(T2DM). Methods FromJanuarytoApril2008,35patientswithT2DM(groupA1HOMA-IR0.05).TheANP,BNPandDTstagewereallhigherthanthoseingroupB(P0.05).ThevaluesofE/A,e/aandS/DingroupA1andA2werealllowerthanthoseingroupB(P0.05).ThevaluesofLVEFofgroupA1andA2werebothsignificantlyreducedthanthatingroupB(P<0.05),andthevaluesingroupA2werethelowest(P<0.05). Conclusion Withtheaggravatingofinsulinresistance,myocardialcontractilityanddiastolicfunctionwilldecline,meanwhiletheANPandBNPsecretionwillincrease,andthentheclinicalandechocardiographicmanifestationwillappear.
| [1] | Bell DSH. Heart failure: a serious and common comorbidity of diabetes[J]. Clinical Diabetes, 2004, 22(2): 61-65.
|
| [2] | Nielson C, Lange T. Blood glucose and heart failure in nondiabetic patients[J]. Diabetes Care, 2005, 28(3): 607-611.
|
| [3] | Witteles RM, Fowler MB. Insulin-resistant cardiomypathy clinical evidence, mechanisms, and treatment options[J]. J Am Coll Cardiol, 2008, 51(2): 93-102.
|
| [4] | 包哈申, 柳景华, 刘宇扬, 等. 胰岛素抵抗与心力衰竭[J]. 心肺血管病杂志, 2010, 29(3): 259-261.
|
| [5] | Wallace TM, Matthews DR. The assessment of insuin resistance in man[J]. Diabet Med, 2002,19(7): 527-534.
|
| [6] | 李秀钧. 胰岛素抵抗综合症[M]. 2版. 北京: 人民卫生出版社, 2007: 3.
|
| [7] | Ford ES, Giles WH. A comparison of the prevalence of the metabolic syndrome using two proposed definitions[J]. Diabetes Care, 2003, 26(2): 575-581.
|
| [8] | 刑小燕, 杨文英, 杨兆军, 等. 胰岛素抵抗指数在不同糖耐量人群中诊断代谢综合征的作用[J]. 中华糖尿病杂志, 2004, 12(3): 182-186.
|
| [9] | Regan TJ, Lyons MM, Ahmed SS, et al. Evidence for cardiomyopathy in familial diabetes mellitus[J]. J Clin Invest, 1997, 60(5): 885-887.
|
| [10] | Longnus SL, Wambolt RB, Ban RI, et al. Regulation of myocardial fatty acid oxidation by sustrate supply[J]. Am J Physiol Heart Circ Physiol, 2001, 281(4): H1561-H1567.
|
| [11] | Kelly D. Whrtworth JA. Endothelin-1 as a mediator in cardiovascular disease[J]. Clin Exp Pharmacol Physiol, 1999, 26(2): 158-161.
|
| [12] | 许朝祥, 杜心清, 许有容, 等. 胰岛素抵抗与充血性性心力衰竭[J]. 心血管病学进展, 2001, 22(6): 334-337.
|
| [13] | 殷丽琼, 吴继雄. 胰岛素抵抗与高血压病左室肥厚、心力衰竭的关系[J]. 安徽医科大学学报, 2005, 40(2): 173-175.
|
| [14] | Fredersdorf S, Thumann C, Ulucan C, et al. Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats[J]. Cardiovasc Pathol, 2004, 13(1): 11-19.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
