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华西医学  2011 

舒林酸治疗结直肠息肉有效性及安全性的系统评价

, PP. 81-84

Keywords: 结直肠息肉,舒林酸,有效性,不良反应,系统评价

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Abstract:

【】 目的 评价舒林酸治疗结直肠息肉的有效性和安全性。 方法 计算机检索PubMed、CochraneIibrary、Embase、SCI、CNKI、万方、维普、CBM数据库。按Cochrane系统评价的方法评价纳入研究质量,并进行Meta分析。 结果 共纳入7个随机对照试验(RCT),共235例患者。Meta分析结果显示舒林酸治疗腺瘤性息肉病(FAP)在有效率、息肉消失率方面与安慰剂比较,差异无统计学意义(P>0.05);治疗散发性结肠腺瘤性息肉病(SCAP)在有效率、息肉消失率、腺瘤直径变化方面与安慰剂比较,差异有统计学意义(P0.05).Thereweresignificantdifferencesintheeffectiverate,polypsdisappearancerateandsizeofadenomasbetweenthetwogroups(P<0.05);themostcommonadverseeventwasthesymptomsofdigestivetractwhichdifferedmuchfromthatintheplacebogroup(P<0.05). Conclusion ThetherapeuticeffectofsulindaconFAPisnotsure,butitiseffectiveonSCAP.

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