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华西医学  2012 

盐酸氨基葡萄糖治疗椎间盘源性腰痛的随机对照研究

, PP. 1818-1821

Keywords: 盐酸氨基葡萄糖,椎间盘源性腰痛,非甾体抗炎药

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Abstract:

目的 探讨单用和联用盐酸氨基葡萄糖与非甾体抗炎药(NSAID)在椎间盘源性腰痛(DLBP)治疗中的有效性。方法 2011年1月-12月72例DLBP患者,男42例,女30例;年龄22~71岁;体重43~84kg;病程0.5~10年。通过随机数字表的方法,将患者分为3组。A组给予盐酸氨基葡萄糖胶囊750mg,2次/d,同时给予尼美舒利分散片100mg,2次/d;B组给予盐酸氨基葡萄糖胶囊750mg,2次/d;C组给予尼美舒利分散片100mg,2次/d。3组均用药8周后停药,用药期间停用其他活血化瘀类药物及物理治疗。选取治疗前及治疗后第4、8、16周4个时间点,运用疼痛数字评价量表(NRS)、Oswestry功能障碍指数(ODI)、生活质量评价量表SF-36分别对3组患者的腰痛、腰部功能及生活质量进行评价。结果 63例获得随访,失访率12.5%。各组患者NRS评分、ODI评分、SF-36评分在治疗前后比较差异均有统计学意义(P<0.05),A组疗效明显优于B、C两组,B组治疗后各项数据较治疗前明显改善(P<0.05)。结论 单用盐酸氨基葡萄糖治疗DLBP有效,且在停药后,仍有一定疗效,联用NSAID效果更佳;远期疗效有待进一步随访。

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