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华西医学  2012 

缺氧诱导因子-1α与糖尿病周围神经病变

, PP. 1737-1740

Keywords: 缺氧诱导因子,糖尿病周围神经病变,血管内皮生长因子,促红细胞生成素

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Abstract:

糖尿病周围神经病变是糖尿病最常见的慢性并发症之一。缺血、缺氧在糖尿病周围神经病变中起着重要作用,而缺氧可刺激缺氧诱导因子(HIF)-1α表达增强。HIF-1α可增强细胞对低氧的适应能力,对多种细胞具有保护作用,亦可直接抑制神经细胞凋亡以及调节其下游基因血管内皮生长因子、促红细胞生成素等的表达,可能对糖尿病周围神经发挥保护作用。

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