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华西医学  2012 

胰胆管合流异常与胆囊癌关系的Meta分析

, PP. 1162-1167

Keywords: 胰胆管合流异常,胆囊癌,Meta分析

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Abstract:

目的 综合评价胰胆管合流异常(PBM)与胆囊癌发生的关系,为胆囊癌的预防提供更多、更准确的信息。方法 计算机检索中国生物医学文献数据库(CBM)、中国期刊网(CNKI)、PubMed、EMBASE、万方等数据库,检索时间从1977年4月-2011年5月,并结合文献追溯的方法,收集国内外公开发表的关于PBM与胆囊癌关系的病例对照研究或队列研究,采用RevMan5.0.25软件进行Meta分析。结果 总计纳入文献8篇,其中3篇仅对比分析了PBM在胆囊癌患者与正常对照组中发生率的差异,2篇仅对比分析了胆囊癌在PBM患者与正常对照组中发生率的差异,而另外3篇文献则对这两种发生率的差异都进行了对比。Meta分析结果显示胆囊癌患者中PBM的发生率明显高于正常对照组,差异有统计学意义OR=7.41,95%CI(5.03,10.87),P<0.00001;且PBM患者中胆囊癌的发生率明显高于正常对照组,差异有统计学意义OR=17.67,95%CI(10.43,29.94),P<0.00001。结论 PBM是胆囊癌发生的高危因素,与胆囊癌的发生密切相关。

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