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华西医学  2012 

抗菌药物与细胞色素P450的相关研究

, PP. 982-984

Keywords: 细胞色素P450,抗菌药物,药物代谢,药物相互作用

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Abstract:

抗菌药物广泛地应用于临床各个科室,常常与多种药物联合应用而产生药物相互作用。肝微粒体细胞色素P450是药物代谢最重要的酶系之一,药物作用影响其活性是发生药物相互作用的重要分子机制。了解抗菌药物与细胞色素P450的相关关系,有助于明确药物相互作用的分子基础,有助于指导临床合理联合用药,保障临床治疗更加安全有效。现就抗菌药物与细胞色素P450的相关研究作一综述。

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