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华西医学  2012 

乳腺癌患者激素受体、人表皮生长因子受体2表达与免疫组织化学分子亚型分析

, PP. 491-494

Keywords: 乳腺癌,雌激素受体,孕激素受体,人表皮生长因子受体2,分子亚型

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Abstract:

目的 研究乳腺癌患者雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER-2)表达情况及免疫组织化学分子亚型分布。方法 对2003年1月-2008年9月四川大学华西医院病理科3365例乳腺癌病理报告存档资料进行激素受体(ER/PR)、HER-2表达情况及免疫组织化学分子亚型分布进行分析。结果 3365例确诊的乳腺癌患者中,ER阳性1824例(54.2%),PR阳性1841例(54.7%),HER-2过表达284例(8.4%)。相关分析显示ER与PR表达呈正相关(P<0.001),HER-2与ER、PR表达均呈负相关(P<0.001)。免疫组织化学分子亚型结果显示luminalA型最常见,为1993例(59.2%);basal-like型为623例(18.5%);HER-2过表达型为169例(5.0%);luminalB型最少,为115例(3.4%);未分类的为465例(13.8%)。结论 乳腺癌患者激素受体及HER-2表达有特殊性,激素受体阳性率>50%,HER-2阳性率在不同研究中显示出不同的结果,尚需进一步研究;ER、PR与HER-2具有良好的相关性;免疫组织化学分子亚型中luminalA型最常见。

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