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华西医学  2012 

中医药随机对照试验与我国疾病负担的关系

, PP. 538-541

Keywords: 中医药,随机对照试验,疾病负担,死亡率,伤残调整寿命年

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Abstract:

目的 评估中医药临床研究是否与我国主要疾病负担相关。方法 首先从1999年-2004年出版的13种中医、中西医结合杂志中手工检索出随机对照试验(RCT),并提取出杂志名称、出版年限、治疗的疾病类别及样本含量等数据。然后采用死亡率和伤残调整寿命年(DALY)作为衡量标准,统计2002年我国疾病负担前30位病因的RCT数量,采用秩相关分析这些疾病负担与发表的中医药RCT及其受试者数量的关系。结果 最终确认7422个RCT,约38%的RCT来自于3种国家级杂志。这些RCT覆盖了我国疾病负担中的主要病种,其中4280个RCT(57.7%)研究前30位病因合并产生的42个病种,只有3个病种(7%)没有任何RCT研究。采用DALY得到的相关系数分别是0.108(P=0.569)、0.092(P=0.628),通过死亡率产生的相关系数分别是0.453(P=0.012)、0.536(P=0.002)。结论 中医药RCT与采用死亡率衡量的疾病负担明显相关,但采用DALY分析却未发现二者存在相关性。中医药临床研究可能更注重死亡率高的病种,一定程度上忽略了DALY衡量的疾病负担。

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