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华西医学  2012 

多发性肌炎外周血白细胞中细胞因子信号转导蛋白抑制因子基因表达的初步研究

, PP. 481-484

Keywords: 细胞因子信号转导蛋白抑制因子,细胞因子诱导的含SH2区域蛋白,多发性肌炎

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Abstract:

目的 研究活动期多发性肌炎患者外周血白细胞细胞因子信号转导蛋白抑制因子(SOCS)1、SOCS2、SOCS3和细胞因子诱导的含SH2区域蛋白1(CIS)与正常人表达的差异,探讨SOCS在多发性肌炎发病中可能的作用。方法 2011年6月-12月,采用实时荧光定量聚合酶链反应法检测了14例活动期多发性肌炎患者和14例正常人外周血白细胞中SOCS1、SOCS2、SOCS3和CIS1基因的相对表达量。结果 与对照组相比,多发性肌炎症患者外周血白细胞基因SOCS1~3表达明显降低(P值均<0.05),CIS1基因的表达较对照组明显升高(P<0.05),差异有统计学意义。结论 SOCS基因家族可能参与了多发性肌炎的发病,该蛋白分子家族的成员可能会成为多发性肌炎治疗的一种新的候选基因。

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