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华西医学  2012 

体外循环行肺动脉灌注液对术后肺功能的保护

, PP. 347-349

Keywords: 肺动脉灌注,肺保护,体外循环

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Abstract:

目的 探讨体外循环(CPB)期间行肺动脉灌注液对术后肺功能的保护作用。方法 2007年1月-2011年4月30例在CPB下行单纯二尖瓣人工机械瓣置换术患者,随机分成肺保护组和对照组各15例,肺保护组患者CPB期间经肺动脉灌注低温肺保护液,对照组患者CPB期间未经肺动脉灌注低温肺保护液。监测两组患者在麻醉诱导后、阻断主动脉l0min及开放主动脉l0min,2、12、24h各时间点的呼吸指数(RI)、氧合指数(OI)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)及术前、术后肺动脉压力(PAPm)、静态肺顺应性(CLS)、气道阻力(AR)变化,并比较术后ICU监护时间、术后呼吸机辅助时间、住院天数及有无术后并发症等。结果 两组IL-6、TNF-α、RI、OI、PAPm、AR、CLS比较差异均有统计学意义(P<0.05)。但术后ICU监护时间及住院时间比较差异均无统计学意义(P>0.05)。结论 CPB期间行肺动脉灌注对术后肺功能具有保护作用。

References

[1]  [ 1 ] Ng CS, Wan S, Yim AP, et al. Pulmonary dysfunction after cardiac surgery[J]. Chest, 2002, 121(4): 1269-1277.
[2]  [ 2 ] Paparella D, Yan TM, Young E. Cardiopulmonary bypass induced inflammation pathophyaiology and trestment. An update[J]. Eur J Cardiothoacsurg, 2002, 21(2): 232-244.
[3]  [ 3 ] 林柏松, 张秀和, 张柏民, 等. 肺动脉灌注肺保护液对体外循环相关性炎症反应影响的实验研究[J]. 中国实验诊断学, 2010, 14(2): 1007-4287.
[4]  [ 4 ] 魏波, 刘迎龙, 于存涛, 等. 肺动脉灌注低温肺保护液减轻体外循环肺内炎性反应[J]. 中华胸心血管外科杂志, 2004, 20(1): 4-6.
[5]  [ 5 ] Asimakopoulos G, Smith P, Ratnatunga C, et al. Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass[J]. Ann Thomc Surg, 1999, 68(3): 1107-1115.
[6]  [ 6 ] Scholz M, Simon A, Marheis G, et al. leukocyte filtration fails to limit functional neutrophil activity during cardiac surgery[J]. Inflamm Res, 2002, 51(7): 363-368.
[7]  [ 7 ] Sutton SW, Patel AN, Chase VA, et al. Clinical benefits of continuous leukocyte filtration during cardiopulmonary bypass in patients undergoing valvular repair or replacement[J]. Perfusion, 2005, 20(1): 21-29.
[8]  [ 8 ] Clark SC. Lung injury afer cardiopulmonary bypass[J]. Perfusion, 2006, 21(4): 225-228.
[9]  [ 9 ] Taggart DR, EI-Fiky M, Carter R, et al. Respiratory dysfunction after uncomplicated cardiopulmonary bypass[J]. AnnThomc Surg, 1993, 56(5): 1123-1128.
[10]   Türk?z R, Y?rükolu K, Akcay A, et al. The effect of pentoxifylline on the lung during cardiopulmonary bypass[J]. EurJ Cardiothorac Surg, 1996, 10(5): 339-346.
[11]   Serraf A, Aznag H, Baudet B, et al. Pulmonary vascular endothelial growth factor and nitric oxide interaction during total cardiopulmonary bypass in neonatal pigs[J]. Thorac Cardiovasc Surg, 2003, 125(5): 1050-1057.
[12]   Wan S, Desmet JM, Barvais L, et al. Myocardium is amajor source of proinflammatory cytokines in patient undergoing cardiopulmonary bypass[J]. Thorac Cardiovasc Surg, 1996, 112(3): 806-811.
[13]   Liebold A, Keyl L, Bimbaum DE, et al. The heart produces, but lungs consume proinflammatory cytokines following cardiopulmonary bypass[J]. Cardiothorac Surg, 1999, 15(3): 340-345.
[14]   Camey DE, Lntz CJ, Picone AL, et al. Soluble tumor necrosis factor receptor prevents post-pump syndrome[J]. J Surg Res, 1999, 83(2): 113-121.
[15]   Wei B, Liu YL. Lung perfusion with protective solution relieves lung injury in corrections of tetralogy of fallet[J]. Ann Thorac Surg, 2004, 77(3): 918-924.
[16]   Liu YL, Wang Q. Pulmonary artery perfusion with protective solution reduces lung injury after cardiopulmonary bypass[J]. Ann Thorac Surg, 2000, 69(5): 1402-1407.

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