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华西医学  2013 

原发性干燥综合征周围神经病变与干燥综合征A型/B型抗体的关系研究

DOI: 10.7507/1002-0179.20130588, PP. 1862-1864

Keywords: 原发性干燥综合征,周围神经病变,干燥综合征A型抗体,干燥综合征B型抗体

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Abstract:

目的 探讨原发性干燥综合征周围神经病变的发生与干燥综合征A型/B型抗体(抗SSA/SSB抗体)的关系。方法 纳入2009年1月-2011年12月期间门诊及住院收治的原发性干燥综合征患者88例。所有患者均接受神经系统检查,采用蛋白质印迹法检测抗SSA抗体和抗SSB抗体,利用全自动化学发光仪检测血清维生素B12水平。结果 88例原发性干燥综合征患者中有27例(30.7%)存在周围神经病变。有或无周围神经病变的患者在年龄、性别、病程等一般情况方面无明显不同。有周围神经病变和无周围神经病变的原发性干燥综合征患者抗SSA抗体阳性率分别为70.4%(19/27)、70.5%(43/61),差异无统计学意义(χ2=0.000,P=0.991);抗SSA/SSB抗体双阳性率分别为63.0%(17/27)、14.8%(9/61),差异有统计学意义(χ2=17.416,P=0.000);血清维生素B12水平分别为(390±55)、(410±86)pg/dL,差异无统计学意义(t=0.908,P=0.370)。结论 周围神经病变在原发性干燥综合征患者中较常见,且周围神经病变的发生多伴随血清抗SSA/SSB抗体阳性。

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