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华西医学  2013 

卵巢早衰患者CD4+CD25+调节性T细胞的变化及干扰素-γ、转化生长因子-β1的表达

DOI: 10.7507/1002-0179.20130120, PP. 377-379

Keywords: 卵巢功能早衰,T淋巴细胞,调节性,干扰素Ⅱ型,转化生长因子-β1

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Abstract:

目的 通过观察卵巢早衰POF患者外周血CD4+CD25+调节性T细胞Treg及干扰素-γ(IFN-γ)、转化生长因子-β(TGF-β)的变化,探讨POF的免疫学发病机制。方法 收集2011年12月-2012年9月就诊的POF患者17例,卵巢储备功能减退DOR患者11例,以及生殖中心健康育龄女性16例,流式细胞仪定量检测外周血Treg数量,Elisa方法检测血清IFN-γ、TGF-β的水平,并以FSH/LH评价卵巢储备功能,进行相关性分析。结果 与对照组相比,POF组和DOR组IFN-γ水平增高P<0.01、TGF-β水平降低P<0.01,POF患者及DOR患者Treg比例降低P<0.01,IFN-γ的增高与卵巢储备功能的下降呈显著正相关r=0.70,P<0.01。结论 Treg和IFN-γ、TGF-β水平与卵巢早衰密切相关,IFN-γ对评估卵巢储备功能、预测卵巢早衰具有参考价值。

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