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华西医学  2014 

蛋白尿对腹膜透析患者残余肾功能的影响探讨

DOI: 10.7507/1002-0179.20140667, PP. 2205-2208

Keywords: 慢性肾脏病,腹膜透析,蛋白尿,残余肾功能,影响因素

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Abstract:

目的 探讨不同蛋白尿水平与腹膜透析患者残余肾功能(RRF)的关系。方法 收集2011年1月-2013年1月开始腹膜透析的45例患者资料,根据其初始尿蛋白水平分为大量蛋白尿(n=20)及非大量蛋白尿组(n=25)并定期随访,研究蛋白尿及可能对RRF下降相关的影响因素。结果 随访12个月后RRF>基线50%的患者在大量蛋白尿组和非大量蛋白尿组分别为13例(65%)和20例(80%),差异有统计学意义(P<0.05),而单因素及多因素分析则提示非大量蛋白尿、较高基础残余肾小球滤过率(rGFR)在RRF下降中具有保护作用(P<0.05)。结论 对于腹膜透析患者来说,大量蛋白尿、更低的基线rGFR预示着RRF的下降更显著,因而降低尿蛋白的治疗措施可能有利于保护RRF,从而改善腹透患者生存质量。

References

[1]  [ 1 ] Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney disease in China: a cross-sectional survey[J]. Lancet, 2012, 379(9818): 815-822.
[2]  [ 2 ] Kang SH, Cho KH, Park JW, et al. Risk factors for mortality in stable peritoneal dialysis patients[J]. Ren Fail, 2012, 34(2): 149-154.
[3]  [ 3 ] Tam P. Peritoneal dialysis and preservation of residual renal function[J]. Perit Dial Int, 2009, 29(Suppl 2): S108-S110.
[4]  [ 4 ] 王丽妍, 张东亮, 刁宗礼, 等. 透析患者残余肾功能的保护[J]. 中国血液净化, 2012, 11(2): 95-98.
[5]  [ 5 ] Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage[J]. J Am Soc Nephrol, 2006, 17(11): 2974-2984.
[6]  [ 6 ] Singhal MK, Bhaskaran S, Vidgen E, et al. Rate of decline of residual renal function in patients on continuous peritoneal dialysis and factors affecting it[J]. Perit Dial Int, 2001, 20(4): 429-438.
[7]  [ 7 ] 陈香美. 中国腹膜透析技术发展现状与未来[J]. 中国实用内科杂志, 2013, 33(6): 413-415.
[8]  [ 8 ] 龚蓉, 陈泽君, 皮婧婧, 等. 三级医院与社区医院联合管理居家腹膜透析患者实践效果的初讨[J]. 华西医学, 2014, 29(5): 831-834.
[9]  [ 9 ] Paniagua R, Amato D, Voneshi E, et al. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial[J]. J Am Soc Nephrol, 2002, 13(5): 1307-1320.
[10]   Bargman JM, Thorpe KE, Churchill DN, et al. Relative contribution of residual renal function and peritoneal clearance to adequacy of dialysis: a reanalysis of the CANUSA study[J]. J Am Soc Nephrol, 2001, 12(10): 2158-2162.
[11]   Moist LM, Port FK, Orzol SM, et al. Predictors of loss of residual renal function among new dialysis patients[J]. J Am Soc Nephrol, 2000, 11(3): 556-564.
[12]   Liao CT, Shiao CC, Huang JW, et al. Predictors of faster decline of residual renal function in Taiwanese peritoneal dialysis patients[J]. Perit Dial Int, 2008, 28(Suppl 3): S191-S195.
[13]   Kolesnyk I, Noordzij M, Dekker FW, et al. Treatment with angiotensinⅡ inhibitors and residual renal function in peritoneal dialysis patients[J]. Perit Dial Int, 2011, 31(1): 53-59.
[14]   Reyes-Marín F, Calzada C, Ballesteros A, et al. Comparative study of enalapril vs. losartan on residual renal function preservation in automated peritoneal dialysis. A randomized controlled study[J]. Rev Invest Clin, 2012, 64(4): 315-321.
[15]   Akbari A, Knoll G, Ferguson D, et al. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in peritoneal dialysis: systematic review and meta-analysis of randomized controlled trials[J]. Perit Dial Int, 2009, 29(5): 554-561.
[16]   Ryckelynck JP, Goffin é, Verger C, et al. Maintaining residual renal function in patients on dialysis[J]. Nephrol Ther, 2013, 9(6): 403-407.
[17]   Liu JH, Wang SM, Chen CC, et al. Relation of ankle-brachial index to the rate of decline of residual renal function in peritoneal dialysis patients[J]. Nephrology (Carlton), 2011, 16(2): 187-193.

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