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华西医学  2014 

心脏生物标志物联合肺栓塞严重程度指数对急性肺栓塞症诊断及危险分层的研究

DOI: 10.7507/1002-0179.20140373, PP. 1208-1212

Keywords: 急性肺栓塞,B型钠尿肽,肌钙蛋白I,肺栓塞严重程度指数,诊断,危险分层

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Abstract:

目的 检测急性肺栓塞(APE)患者血浆中B型钠尿肽(BNP)和肌钙蛋白I(cTnI)的浓度,研究肺栓塞严重程度指数(PESI)、cTnI、BNP对APE诊断及预后的预测价值。方法 选取2010年1月-2013年1月确诊的共96例APE患者,同时选取同期非APE对照者50例。对入选者进行肺栓塞严重指数(PESI)评分,据分值大小分为低危组、中危组、高危组;根据cTnI与BNP结果分组为阳性组及阴性组。分析PESI、cTnI和BNP在APE患者诊断与危险分层的预测价值。结果 APE患者中低危、中危与高危各组大面积、次大面积APE构成比随组别增高而升高(P<0.01);cTnI阳性组大面积、次大面积APE占82.9%,cTnI阴性组非大面积APE占81.9%;BNP阳性组大面积、次大面积APE占73.3%,BNP阴性组非大面积APE占86.3%。cTnI、BNP阳性组右心功能不全、心源性休克及死亡的发生率明显高于阴性组(P<0.01)。结论 联合检测cTnI、BNP结合PESI评分在APE的诊断和危险分层中具有重要意义。

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