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木本药用植物红豆杉研究的新进展

Keywords: 红豆杉,人工栽培,紫杉醇,化学半合成,细胞培养,内生真菌,代谢工程

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Abstract:

红豆杉是当今十分重要的一种木本药用植物,从中提取出的二萜类抗癌化合物紫杉醇在全世界已广泛应用于卵巢癌、乳腺癌、非小细胞肺癌等癌症的临床治疗,效果显著.近年来,人们还发现紫杉醇在其它疾病的治疗中也具有很好的作用.本文综述了近年来国内外在红豆杉人工栽培、紫杉醇化学半合成、红豆杉细胞培养、产紫杉醇内生真菌培养、代谢工程方面的最新研究进展,对当前工作中存在的问题进行了探讨,并对有关研究的发展前景进行了展望.

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