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糖尿病患者尿液中13种微量元素含量及其与血糖的相关性

, PP. 193-196

Keywords: 糖尿病,尿液,微量元素

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Abstract:

目的通过检测糖尿病患者和健康对照者尿液中砷、镉、钴、铬、铜、铁、锂、镍、锰、铅、硒、钒、锌13种微量元素的含量,统计分析两组人群尿液元素的差异性,以及元素与血糖的相关性。方法随机选取了100例糖尿病患者,选取性别和年龄相匹配的健康对照者110人,收集研究对象的晨尿,将尿液用3%(W/V)的硝酸及内标液等稀释20倍后直接用电感耦合等离子体质谱仪进行检测。用SAS9.2对数据进行统计学分析。结果糖尿病患者尿液中砷、铜、镍、锰、硒、钒、锌的含量比健康对照组高,差异具有统计学意义(P<0.05)。其中锌在糖尿病组和健康对照组的中位数和四分位数M(Q25,Q75)分别是481.98(315.27,674.79)μg/g肌酐、323.43(200.16,418.60)μg/g肌酐,差异具有统计学意义(Z=5.74,P<0.0001)。Spearman等级相关分析显示上述7种元素与空腹血糖呈正相关,其中锌与血糖的相关性最强(rs=0.37,P<0.0001)。结论砷、铜、镍、锰、硒、钒、锌在糖尿病患者与健康者尿液中的含量存在统计学差异,且与空腹血糖呈正相关。

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