Justice R W,Zilian O,Woods D F,et al．The Drosophila tumor sup-pressor gene warts encodes a homolog of human myotonic dystrophy ki-nase and is required for the control of cell shape and proliferation [J]．Genes Dev,1995,9(5)：534-546．
[5]
Wang W,xu T,Zhang S,et a1．Identifying tumor suppressors in genetic mosaics：The Drosophila lats gene encodes a putative protein kinase [J].Development,1995,121(4)：1053-1063．
[6]
Chan S W,Lim C J,Chen L,et a1.The Hippo pathway in biological con-trol and cancer development [J].J Cell Phusi01,2011,226(4):928-939．
[7]
Huang J B,Wu S,Barrera J,et a1．The Hippo signaling pathway coor-dinately regulates cell proliferation and apoptosis by inactivating Yor-kie,the Drosophila homolog of YAP [J].Cell,2005,122(3):421-434．
[8]
Pan D.The Hippo signaling pathway in development and cancer [J].Dev Cell,2010,19(4):491-505．
[9]
Zhao B,Tumaneng K,Guan KL. The Hippo pathway in organ size con-trol,tissue regeneration and stem cell self-renewal [J].Nat Cell Biol,2011,13(8):877-883.
[10]
Kowalik MA,Saliba C,Pibiri M,et al. Yes-associated protein regula-tion of adaptive liver enlargement and hepatocellular carcinoma de-
[11]
velopment in mice [J].Hepatology,2011,53(6):2086-2096.
[12]
Camargo FD, Gokhale S, Johnnidis JB, et al. YAP1 increases organ size and expands undifferentiated progenitor cells [J].Curr Biol,2007,17(23):2054-2060.
Lu L,Li Y,Kim SM,et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver [J].Proc Natl Acad Sci USA,2010,107(4):1437-1442.
[15]
Zhang J,Smolen GA,Haber DA.Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo path- way [J].Cancer Res,2008,;68(8):2789-2794.
[16]
Li H,Wolfe A,Septer S,et al. Deregulation of Hippo kinase signaling in human hepatic malignancies [J]. Liver Int,2012,32(1):38-47.
[17]
Xu MZ,Chan SW,Liu AM,et al. AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma [J].Oncogene,2011,30(10):1229-1240.
[18]
Xu MZ,Yao TJ,Lee NP,et al. Yes-associated protein is an indepen-dent prognostic marker in hepatocellular carcinoma [J].Cancer,2009,115(19): 4576-4585.
[19]
Liu AM,Poon RT,Luk JM. MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties [J]. Bio-chem Biophys Res Commun,2010,394(3):623-627.
[20]
Ma O,Cai WW,Zender L,et al. MMP13,Birc2 (cIAP1),and Birc3 (cIAP2),amplified on chromosome 9,collaborate with p53 deficiencyin mouse osteosarcoma progression [J]. Cancer Res,2009,69(6):2559-2567.
[21]
Lamar Jm,Stem P,Liu H,et a1.The Hippo pathway target,YAP,pro-motes metastasis through its TEAD-interac-tion domain [J].Proc Natl Acad Sci U S A,2012,1I：2441-2450.
[22]
Pobbati AV,Hong W.Emerging roles of TEAD transcription factors and its coactivatom in eancem [J].Cancer Biol Ther,2013,4:390-398.
[23]
I_Y,Hibbs MA,Gard AL,et a1.Genome-wide analysis of N1 1CD/RB-PJ targets in vivo reveals direct transcriptionalregulation of Wnt,SHH,and hippo pathway effectorsby Notchl [J].Stem Cells,2012,30:741-752.
