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ICOS+Treg与B10细胞在AD患者发病机制中的作用

, PP. 412-414

Keywords: 特应性皮炎,B10细胞,ICOS+Treg细胞

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Abstract:

目的研究特应性皮炎(AtopicDermatitis,AD)患者外周血中B10细胞与ICOS阳性调节性T细胞(ICOS+Treg)比例变化,探讨它们在AD发病机制中的作用。方法收集35例AD患者外周血,流式细胞仪(FCM)检测B10细胞、ICOS+Treg、ICOS-Treg细胞的数量及ICOS+Treg/ICOS-Treg,用FCM测定外周血单核细胞(PBMC)培养后分泌IL-10、TGF-β、IL-17水平,与同期对照组比较并与患者的病情进行相关分析。结果AD活动期患者PBMC中B10细胞、ICOS+Treg细胞与ICOS+Treg/ICOS-Treg均低于对照组[(0.64±0.22)%Vs(1.62±0.47)%,PPPP>0.05),B10细胞的数量和ICOS+Treg/ICOS-Treg与疾病程度呈负相关(P<0.05);AD患者PBMC分泌内因子IL-10、TGF-β下降,而IL-17水平升高。结论B10细胞与ICOS+Treg及相关细胞因子的变化可能与AD的免疫机制及疾病状态有关。

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