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间接免疫荧光法检测20170例患者抗核抗体的结果分析

, PP. 477-480

Keywords: 间接免疫荧光法,自身免疫性疾病,抗核抗体

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Abstract:

目的探讨抗核抗体(Antinuclearantibodies,ANA)的阳性率及对诊断自身免疫性疾病(Autoimmunediseases,AID)的意义。方法采用间接免疫荧光法(Indirectimmunofluorescence,IIF)检测20170例患者的血清ANA。符合AID诊断的患者869例,包括系统性红斑狼疮(Systemiclupuserythematosus,SLE)415例、类风湿关节炎(Rheumatoidarthritis,RA)191例、多发性肌炎/皮肌炎(Polymyositis/Dermatomyositis,PM/DM)68例、干燥综合征(Sjogrensyndrome,SS)102例及系统性硬化症(Systemicsclerosis,SSc)93例。选取非AID患者150例为疾病对照组。结果20170例患者ANA阳性7469例,阳性率为37%,其中男性ANA阳性率(19%)低于女性(44%)(PPP<0.01,其中SLE的阳性率最高(95%)。AID组患者滴度以≥1100为主,疾病对照组滴度以<1100为主。结论IIF法检测ANA对AID的诊断和治疗有重要意义。

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