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T淋巴亚群及T-SPOT.TB检测对活动性结核病的鉴别诊断

, PP. 393-396

Keywords: 活动性结核,隐性结核感染,T,细胞亚群,T细胞斑点试验

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Abstract:

目的探讨T淋巴细胞亚群及结核感染T细胞斑点试验(T-SPOT.TB)检测对活动性结核病的鉴别诊断价值。方法检测20例健康对照者、26例隐性结核病感染者及35例活动性结核杆菌感染者外周血的T淋巴细胞亚群及T-SPOT.TB。结果隐性感染组、活动性结核组的CD4+细胞、CD8+细胞的表达与健康对照组比较有显著性差异(P均P>0.05)。外周血的CD4+CD25+CD127low细胞、CD39+CD4+CD25+CD127low细胞在健康对照组、隐性感染组及活动性结核组中表达有显著性差异(P均P>0.05)。结论CD4+CD25+CD127low细胞与CD39+CD4+CD25+CD127low细胞在活动性结核与隐匿性结核的表达差异或与免疫抑制和免疫耐受的强度有关,是区分二者的优选指标。

References

[1]  Stokes RW ,Waddell SJ.Adjusting to a new home Mycobacterium tuberculosis gene expression in response to an intracellular lifestyle[J].Future Microbiol,2009,4(10);1317-1335.
[2]  Kleinnijenhuis J,Oosting M,Joosten LA,et al.Innate immune recognition of Mycobacterium tuberculosis[J].Clin Dev Immunol,2011:405310.
[3]  OGarra A,Redford P S,McNab F W ,et al.The Immutune Resonse in Tuberculosis [J].Annu Rev Immunol,2013,31:474-527.
[4]  Axelsson-Robertson R,Loxton AG,Walzl G,ea al.A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis[J].PloS One,2013,8(3):58309-58309.
[5]  Janssens JP,Roux-Lombard P,Perneger T,et al.Quantitative scoring of an interferon-gamma assay for differentiating active form latent tuberculosis[J].Eur Respir J ,2007,30(4):722-728.
[6]  Pulte ED,Broekman MJ,Olson KE,et al.CD39/NPTDase-1 activity andexpression in normal leukocytes[J].Thromb Res,2007,121:309-317.
[7]  Kim K,Perera R,Tan DB,et al. Circulating mycobacterial-reactive CD4 + T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection[J].Tuberculosis,2014,94(5):494-501.
[8]  Barry CE 3 rd ,Boshoff HI,Dariois V,Dick T,Ehri S,Flynn J,Schnappinger D,Wilkinson RJ,Young D,The spectrum of latent tuberculosis;rethinking the biology and intervention strategies[J].Nat Rev Microbiol,2009,7(12):845-855.
[9]  Richeldi L,An update on the diagnosis of tuberculosis infection[J].Am J Respir Crit Care Med,2006,174(7):736-742.
[10]  刘二勇,周林,成诗明.结核分枝杆菌潜伏性感染及预防性治疗研究进展的系统评价[J].中国防痨杂志,2013,35(1):231-239.
[11]  中华医学会,临床诊疗手册(结核分册)[M].北京:人民出版社,2005:9.
[12]  United States Department of Health and Human Services Centers for Disease Conftrol and Prevention .Latent tuberculosis infection;a guide for primary health care providers [DB/OL].Atlanta :United States Centers for Disease Control and Prevention, 2010(2010-11-21)[2012-11-16].

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