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过敏原IgE抗体检测在儿童常见过敏性疾病中的临床意义

, PP. 730-733

Keywords: 变应性疾病,过敏原,免疫球蛋白E,儿童

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Abstract:

目的探讨过敏原IgE检测在儿童常见过敏性疾病诊治中的临床价值。方法采用ELISA法对438例0~10岁患有哮喘、荨麻疹和湿疹3类过敏性疾病的儿童检测过敏原IgE,包括食入物7项(鸡蛋、牛奶、鳕鱼等、虾等、牛/羊肉、芒果等和花生等)和吸入物7项(总IgE、尘螨、屋尘、柏树等、豚草等、点青霉等和猫/狗毛皮屑),并对不同年龄段的过敏原检出率进行比较,将检测结果用SPSS18.0进行分析。结果2岁以内患者食入物IgE阳性率高于4~10岁患者(P<0.05),2岁以内患者吸入物IgE阳性率低于2~10岁患者(P<0.05)。哮喘、荨麻疹和湿疹3类患者的过敏原特异性IgE在食入物和吸入物中含量最高的分别是牛奶、虾等、鸡蛋和尘螨、尘螨、柏树等,三种患者在食入物和吸入物中的IgE阳性率分别是25.96%、32.02%、33.70%和68.30%、50.98%、35.91%。结论儿童在2岁以前的过敏原IgE主要以食入物为主,在2岁以后主要以吸入物为主,不同疾病过敏原不同,检测吸入性和食入性过敏原IgE能进一步明确过敏原,对于儿童过敏性疾病的诊治和预防有重要临床意义。

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