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CTL、NK及TIDC在胃腺癌组织中表达及对预后的影响

DOI: 10.13604/j.cnki.46-1064/r.2015.08.21, PP. 984-987

Keywords: 胃腺癌,免疫组织化学,免疫细胞,预后

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Abstract:

目的研究CTL、NK及TIDC在胃腺癌组织中的分布情况及对病人生存与预后的影响。方法将CD8作为细胞毒T淋巴细胞(CTL)的标记物,CD56作为自然杀伤细胞(NK)的标记物,S-100作为肿瘤浸润树突状细胞(TIDC)的标记物,应用免疫组织化学方法检测肿瘤组织中CTL、NK及TIDC的分布和浸润情况。结果80例胃腺癌中,CTL无-轻度浸润的48例,5年生存率为38%;显著浸润的32例,5年生存率为63%;NK细胞无-轻度浸润的50例,5年生存率42%,显著浸润的30例,5年生存率为63%;TIDC无-轻度浸润的52例,5年生存率为37%;TIDC显著浸润的28例,5年生存率为57%;NK/T及TIDC同时显著浸润的24例,5年生存率为67%;无-轻度浸润的32例,5年生存率为47%,经Log-rank检验,NK/T及TIDC显著浸润组和无-轻度浸润组的5年生存率差异有统计学意义(P=0.00)。结论胃腺癌组织中CTL、NK及TIDC显著浸润组的预后和生存时间明显好于轻度浸润组。

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