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山苦茶对TNF-α、CRP和VEGF水平的影响

DOI: 10.13604/j.cnki.46-1064/r.2015.08.23, PP. 990-991

Keywords: 山苦茶,肿瘤坏死因子-α,C反应蛋白,血管内皮生长因子,动脉粥样硬化

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Abstract:

目的研究山苦茶对动脉粥样硬化(Atherosclerosis,AS)大鼠的肿瘤坏死因子α(Tumornecrosisfactor,TNF-α)、C-反应蛋白(C-reactiveprotein,CRP)、血管内皮生长因子(Vascularendothelialgrowthfactor,VEGF)水平的影响。方法一次性腹腔注射700000U维生素D3和高脂饮食建立AS大鼠模型,连续灌胃给予山苦茶高(0.081g/kg)、低剂量(0.026g/kg)9周,处死大鼠,取血液置入EDTA管,1500r/min离心10min,测定上清液中TNF-α、CRP和VEGF水平。结果山苦茶提取物高、低剂量均能显著降低AS大鼠血浆中TNF-α、CRP和VEGF水平(P结论山苦茶可以降低AS状态下炎症介质和血管内皮生长因子水平。

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