全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

铁蛋白与肿瘤的发生发展

, PP. 125-127

Keywords: ,铁蛋白,肿瘤

Full-Text   Cite this paper   Add to My Lib

Abstract:

铁蛋白是一种由肝脏合成的糖蛋白,是体内铁贮存的主要形式,在铁平衡中起重要作用。当体内铁含量增加时,Fer可以将铁摄入并贮存,避免了细胞内高浓度游离铁对细胞的毒性作用;当体内需要铁时,Fer可随时释放铁,供机体需要。近年来研究发现,肿瘤组织可以合成和分泌Fer,Fer水平升高可见于肝癌、肺癌、胰腺癌、乳腺癌、白血病等多种恶性肿瘤中。现就Fer的生物学功能及其与不同类型肿瘤的发生发展的相互关系做一概述。

References

[1]  Wang W,Knovich MA,Coffman LG,et al. Serum ferritin: Past, present and future[J].Biochim Biophys Acta,2010,1800(8):760-769.
[2]  Shpyleva SI,Tryndyak VP,Kovalchuk O,et al.Role of ferritin alterations in human breast cancer cells[J]. Breast Cancer Res Treat, 2011,126(1):63-71.
[3]  Armand P, Kim HT, Cutler CS, et al. Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation[J].Blood, 2007, 109(10): 4586-4588.
[4]  周云英,辜红妮,郑庭亮. 血清CEA、CA199、SF联合检测在胃癌中的临床价值[J].国际检验医学杂志,2010,31(4):345-346.
[5]  李世生. 肿瘤相关糖类抗原CA125、CA153、Fer联合测定对卵巢肿瘤的诊断价值[J].广西医科大学学报,2009,26(6):889-890.
[6]  李琼芬.血清Fer联合4种肿瘤标记物对肺癌的诊断价值[J].海南医学院学报,2012,18(2):171-174.
[7]  黄文海,陈润浩,俞建平,章勇.血清肿瘤标志物检测在乳腺癌诊断中的意义[J].中国临床医学,2012,19(3):323-324.
[8]  Hunter HN,Fulton DB,Ganz T.,et al.The solution structure of hunman hepcidin,a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis[J].J Biol Chem,2002,277(40):376597-376603.
[9]  Alkhateeb AA, Han B, Connor JR. Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages[J]. Breast Cancer Res Treat,2013 ,137(3):733-744.
[10]  Alkhateeb AA and Connor JR. The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis[J]. Biochim Biophys Acta, 2013,1836(2):245-254.
[11]  Kalousová M, Krechler T, Jáchymová M, et al. Ferritin as an independent mortality predictor in patients with pancreas cancer. Results of a pilot study[J]. Tumour Biol, 2012, 33(5): 1695-1700.
[12]  Kuvibidila S, Gauthier T, Warrier RP,et al. Increased levels of serum transferring receptor and serum transferring receptor/log ferritin ratios in men withprostate cancer and the implications for body-iron stores[J]. J Lab Clin Med,2004,144(4):176-182.
[13]  Richardson D.R. Iron and neoplasia: Serum transferrin receptor and ferritin in prostate cancer[J]. J Lab Clin Med,2004,144:173-175.
[14]  Ali MA, Akhmedkhanov A, Zeleniuch-Jaquotte A,et al. Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women[J]. Cancer Detect Prev, 2003,27(2):116-121.
[15]  Prutki M, Poljak-Blazi M, Jakopovic M,et al. Altered iron metabo
[16]  lism, transferring receptor 1 and ferritin in patients with colon cancer[J]. Cancer Lett,2006,238(2):188-196.
[17]  Carpagnano GE, Lacedonia D, Palladino GP,et al. Could exhaled ferritin and SOD be used as markers for lung cancer and prognosis prediction purposes?[J].Eur J Clin Invest, 2012, 42(5): 478-486.
[18]  Jézéquel P, Campion L, Spyratos F,et al. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study[J]. Int J Cancer,2012,131(2):426-437.
[19]  方志坚,余延芳,王明迪等.血清Fer测定在急慢性白血病中的临床意义[J].现代中西医结合杂志, 2012, 21(33):3710-3711.
[20]  Sabbah EN, Kadouche J, Ellison D, et al. In vitro and in vivo comparison of DTPA-andDOTA-conjugated antiferritin monoclonal anbody for imaging andtherapy of pancreatic cancer[J]. Nucl Med Biol,2007,34(3):293-304.
[21]  王雪鹏,赵长福,祁海文等.老年脑肿瘤患者脑脊液Fer含量测定的临床意义[J]. 中国老年学杂志,2011,31(02):227-228.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133