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结核病患者外周血T淋巴细胞CD28/CTLA-4表达及意义

, PP. 104-105

Keywords: 结核病,CD28,CTLA-4(CD152)

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Abstract:

目的分析结核病患者外周血共刺激分子CD28/CTLA-4(CD152)表达,评价患者的免疫状态。方法采集21例初诊结核病患者及15例健康对照者外周血,采用多参数流式细胞术检测分析共刺激分子CD28、CD152的表达,以及分析其亚群CD4+CD152+细胞、CD4+CD28+细胞、CD8+CD28+细胞、CD8+CD152+水平的变化。结果与健康者比较,结核病患者外周血CD28+细胞、CD152+细胞水平明显增高(P结论结核病患者外周血共刺激分子CD28/CD152(CTLA-4)表达增加,且CTLA-4在CD4+和CD8+T细胞上表达均增加,提示可能存在T细胞活化或抑制信号调节失衡。

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