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p28GANK在乙肝相关肝癌中表达意义

, PP. 326-327

Keywords: p28GANK,肝癌,免疫组织化学,HBV复制

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Abstract:

目的研究p28GANK在乙肝相关性肝癌组织中表达的临床意义。方法收集乙肝相关的肝癌及对应癌旁组织,采用免疫组织化学检测p28GANK肝癌及其对应癌旁组织中表达差异;分析其在肝癌组织中表达水平与患者临床参数的相关性;分析其表达与HBV复制水平的相关性。结果免疫组化显示p28GANK在肝癌组织表达水平显著高于其对应癌旁组织(P0.05)。结论p28GANK在HBV相关肝细胞癌中表达增强,可能参与HBV-DNA复制,是治疗HBV相关肝癌的重要生物靶点。

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