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老年冠心病患者阿司匹林抵抗的相关因素分析

, PP. 314-316

Keywords: 冠心病,阿司匹林抵抗,老年患者,术后复发,心血管

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Abstract:

目的探讨阿司匹林抵抗的发生率,及阿司匹林抵抗患者的临床特征,发掘出AR发生的相关因素。方法分析2007年1月~2012年1月因冠心病在我院接受治疗的患者的临床资料。比较发生阿司匹林抵抗或半抵抗组与阿司匹林敏感组在合并病史,性别,白细胞(WBC)、红细胞(RBC)、血红蛋白(Hb)、血小板计数(PLT)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-c)、高密度脂蛋白胆固醇(HDL-c)及空腹血糖(FBG)等指标上的差异。结果215例患者中阿司匹林抵抗或半抵抗发生率为27.4%(59/215);阿司匹林抵抗组或半抵抗组合并糖尿病的比率明显高于阿司匹林敏感组,差异具有统计学意义(P结论阿司匹林抵抗现象在临床中确实存在,可能与合并糖尿病、血小板升高、性别有关。其发生抵抗的机制仍需进一步研究。

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