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白介素-1β基因rs1143627-C/T多态性与糖尿病视网膜病变的相关性

, PP. 528-530

Keywords: 白细胞介素-1β,2型糖尿病,糖尿病视网膜病变,单核苷酸

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Abstract:

目的探讨白介素-1β(Interleukin-1β,IL-1β)基因rs1143627-C/T多态性与糖尿病视网膜病变(DR)的相关性。方法应用MassARRAY分子量阵列技术检测154例2型糖尿病(T2DM)并发DR患者(DR组),148例T2DM无并发DR患者(NDR组),142例健康对照者(NC组)白介素-1β基因rs1143627-C/T多态性。检测三组研究对象的血脂、空腹血糖等,并测定体质指数(BMI)。结果DR组与NDR组含T基因型及等位基因T分布频率显著高于NC组,DR组高于NDR组;DR组与NDR组CC基因型及等位基因C分布频率显著低于NC组,DR组低于NDR组,差异均有统计学意义(P结论白介素-1β基因rs1143627-C/T多态性可能与DR发病相关。

References

[1]  Wong TY,Klein R,Islam FM,et al.Diabetic retinopathy in a multi-ethnic cohort in the United States[J].Am J Ophthalmol,2006,14:446-455.
[2]  罗锐 郑晓玲.老年2型糖尿病患者糖尿病视网膜病变相关因素分析[J].海南医学院学报, 2012,18(03):322-324
[3]  Kohnert KD,Augstein P,Zander E,et al.Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents[J].Diabetes Care,2009,32:1058-1062.
[4]  Yang XL, Zou HD, Xu X.Correlation of retinal sensitivity, visual acuity and central macular thickness in different types of diabetic macular edema[J].Chin J Ophthalmo, 2013,49(12):1081-1088.
[5]  罗丽华,王艳玲.糖尿病视网膜病变的病理改变[J].临床和实验医学杂志,2008,7(6):176-177.
[6]  Yang W,Lu J,Weng J,et al.Prevalence of diabetes among men and women in China[J].N Engl J Med,2010,362(25):109-101.
[7]  孙雅彬,董宇.糖尿病视网膜病变的治疗进展[J].吉林医学,2009,7(28):951.
[8]  李仕忠,饶小英,谭旭明.糖尿病性视网膜病变发病机制及临床研究进展[J].白求恩医学院学报,2011,9(2):118-120.
[9]  Takebayashi K,Matsumoto S,Aso Y,et al.Aldosterone block adeattenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy[J].J Clin Endocrinol Metab,2006,91(6):2214-2217.
[10]  Kacso IM1, Potra AR, Rusu A, et al.Relationship of endothelial cell selective adhesion molecule to markers of oxidative stress in type 2 diabetes[J].Scand J Clin Lab Invest,2014 ,74(2):170-176.
[11]  闫俊茹,魏菁.早期糖尿病视网膜病变研究进展[J].医学综述,2010,16(12):1884-1886.
[12]  Maedler K,Sergeev P,Ehses JA,et al.Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets[J].Proc Natl Acad Sci USA,2004,101:8138-8143.
[13]  Storling J,Zaitsev SV,Kapelioukh IL, et al.Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activetion in insulin-secreting cells[J].Endocrinology,2005,146(7):3026-3036.

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