Wemer G, Strommenger B, Klare I, et al．Molecular detection of linezolid resistance in Enterococcus faecium and Enterococcus faecalis by use of 5’nuclease real-time PCR compared to a modified classical approach[J]. J Clin Microbiol, 2004, 42(11): 5327-5331.
[3]
Xiong L, Kloss P. Oxazolidinone resistance mutations in 23srrna of escherichia coli reveal the central region of domain V as the primary site of drug action[J]. J bacteriol, 2000, 182(19): 5325-5331.
[4]
Auckland C, Teare L, Cooke F, et al. Linezolid-resistant enterococci: report of the first isolates in the United Kingdom[J]. J Antimicrob Chemother, 2002, 50(5): 743-746.
[5]
Ager S, Gould K. Clinical update on linezolid in the treatment of Gram-positive bacterial infections[J]. Infect Drug Resist, 2012;5:87-102.
[6]
Long KS, Vester B. Resistance to linezolid caused by modifications at its binding site on the ribosome[J]. Antimicrob Agents Chemother, 2012;56(2):603-612.
[7]
Wang Y, Zhang W, Wang J, et al. Distribution of the multidrug resistance genecfrin Staphylococcus species isolates from swine farms in China[J]. Antimicrob Agents Chemother, 2012, 56:1485-1490.
[8]
Chen H, Wu W, Ni M, et al. Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms[J]. Int J Antimicrob Agents, 2013, 42:317-321.
[9]
Ban N, Nissen P, Hansen J, et al. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution[J]. Science, 2000, 289: 905-920.
[10]
Harms J, Schluenzen F, Zarivach R, et al. High resolution structure of the large ribosomal subunit from a mesophilic eubacterium[J]. Cell, 2001, 107: 679-688.
[11]
Gregory S T, Dahlberg AE. Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23S ribosomal RNA[J]. J Mol Biol, 1999.289: 827-834.
[12]
Roberts MC. Update on macrolide-lincosamide-streptogramin, ke-tolide, and oxazolidinone resistance genes[J]. FEMS Microbiol Lett, 2008,282: 147-159.
[13]
Wittmann HG, Stoffler G, Apirion D, et al. Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins[J]. Mol Gen Genet, 1973,127: 175-189.
[14]
Farrell DJ, Morrissey I, Bakker S, et al. In vitro activities of telithromycin, linezolid, and quinupristin-dalfo-pristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations[J]. Antimicrob Agents Chemother, 2004,48:3169-3171.
[15]
Gregory ST, Dahlberg AE. Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23S ribosomal RNA[J]. J Mol Biol, 1999, 289: 827-834.
[16]
Prunier AL, Trong HN, Tande D, et al. Mutation of L4 ribosomal protein conferring unusual macrolide resistance in two independent clinical isolates of Staphylococcus aureus[J]. Microb Drug Resist, 2005,11:18-20.
[17]
Gentry DR, Rittenhouse SF, McCloskey L, et al. Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects suscep-tibility to retapamulin[J]. Antimicrob Agents Chemother, 2007, 51:2048-2052.
[18]
Miller K, Dunsmore CJ, Fishwick CW, et al. Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center[J]. Antimicrob Agents Chemother, 2008, 52:1737-1742
[19]
Pringle M, Poehlsgaard J, Vester B, et al. Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp[J]. isolates. Mol Microbiol, 2004, 54:1295-1306.
[20]
Prystowsky J, Siddiqui F, Chosay J, et al. Resistance to linezolid: characterization of mutations in rRNA and comparison oftheir occurrences in vancomycin-resistant enterococci[J]. Antimicrob Agents Chemother, 2001, 45(7):2154-2156.
[21]
Bourgeois-Nicolaos N, Massias L, Couson B, et al. Dose dependence of emergence of resistance to Linezolid in Enterococcus faecalis in vivo[J]. J Infect Dis, 2007, 195(10):1480-1488.
[22]
Depaidieu F, Perichon B, Courvalin P. Detection of the van alphabet and ident ification of enterococci and Streptococcus at the species level by multiplex PCR[J]. Clin Microbiol, 2004, 42(12): 5857-5860.
[23]
Lin AH, Murray RW, Vidmar TJ, et al. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin[J]. Antimicrob Agents Chemother, 1997, 41:2127-2131
[24]
Shinabarger DL, Marotti KR, Murray RW, et al. Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions[J]. Antimicrob Agents Chemother, 1997, 41:2132-2136.
[25]
Swaney SM, Aoki H, Ganoza MC, et al. The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria[J]. Antimicrob Agents Chemother, 1998, 42:3251-3255.
[26]
Cai JC, Hu YY, Zhang R, et al. Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China[J]. J Med Microbiol, 2012, 61:1568-1573.
