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二甲双胍对人肺癌细胞A549的增殖和凋亡的影响

DOI: 10.13604/j.cnki.46-1064/r.2015.09.06, PP. 1050-1053

Keywords: 二甲双胍,A549细胞,凋亡,细胞周期蛋白,活性氧自由基

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Abstract:

目的研究二甲双胍(MET)体外对人肺癌A549细胞增殖和凋亡的影响。方法采用MTT法测定MET不同浓度、不同作用时间对A549细胞增殖的抑制作用;用流式细胞术检测A549细胞的凋亡;Westernblot检测细胞周期蛋白CyclinD1表达的变化;ROS荧光探针-DHE测定A549细胞中活性氧自由基(ROS)的含量。结果MET具有抑制人肺癌细胞A549细胞增殖的作用,呈剂量和时间依赖性;MET促进A549细胞的凋亡;MET诱导A549细胞中ROS的生成;MET降低细胞周期蛋白的表达。结论MET抑制人肺癌细胞增殖,诱导细胞凋亡,其机制可能与降低CyclinD1的表达和诱发ROS的生成有关。

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