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海南省恶性疟原虫对青蒿琥酯的敏感性监测

DOI: 10.13604/j.cnki.46-1064/r.2015.10.24, PP. 1241-1243

Keywords: 青蒿琥酯,敏感性,体外微量法,监测,恶性疟原虫

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Abstract:

目的了解恶性疟原虫对青蒿琥酯的敏感性。方法研制成功青蒿琥酯涂药板和便于现场使用的培养基后,1986—2007年采用世界卫生组织(WHO)推荐的体外微量法,在海南省开展了恶性疟原虫对青蒿琥酯的敏感性监测。结果1986—2007年共监测了8次,检测237例病人,完全抑制疟原虫裂殖体形成的平均药浓度,乐东县抱由镇由1986年0.028pmol/μL血升至2002年0.135pmol/μL血,升高至4.82倍(P结论海南省恶性疟原虫对青蒿琥酯敏感性在逐渐下降。

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