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孤独症儿童PUFA和肉毒碱水平与胃肠道反应的相关性研究

DOI: 10.13604/j.cnki.46-1064/r.2015.10.19, PP. 1224-1227

Keywords: 孤独症儿童,胃肠道反应,肉毒碱,多不饱和脂肪酸

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Abstract:

目的研究孤独症儿童血浆多不饱和脂肪酸及血清肉毒碱水平变化,并探讨其是否与胃肠道反应存在相关性。方法选取2012年3月—2015年5月间于张家口市妇幼保健院进行诊治的37例孤独症儿童作为研究对象,并于同时间段内选取与其相匹配的院内体检健康儿童40例作为健康对照组,应用气相色谱法检测所有研究对象血浆中多不饱和脂肪酸水平,应用液相色谱质谱联用法检测血清中肉毒碱水平,比较所得数据并进行统计分析。结果孤独症儿童多不饱和脂肪酸和肉毒碱水平较健康对照组显著降低,ω-6/ω-3比值则显著高于健康对照组。孤独症儿童肉毒碱降低和ω-6/ω-3比值升高呈显著正相关(r=0.61,P结论血浆中多不饱和脂肪酸和血清中肉毒碱水平下降可能与孤独症儿童病程进展有关,同时与胃肠道反应的发生和发展有关。

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