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GADA和ZnT8A与IA-2A在T1DM不同病程阶段的变化特点

, PP. 735-737

Keywords: 糖尿病,自身抗体,锌转运体8,谷氨酸脱羧酶抗体,酪氨酸磷酸酶抗体2

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Abstract:

目的探讨锌转运体8自身抗体(ZnT8A)、谷氨酸脱羧酶抗体(GADA)和酪氨酸磷酸酶抗体2(IA-2A)在1型糖尿病(T1DM)初发病后不同病程的变化。方法60例病程2年(每隔3月复诊)和75例病程5~10年(中位数6.9年)的T1DM患者于初发病和复诊时采集血清,用放免法检测ZnT8A、GADA和IA-2A水平。结果135例T1DM患者初发病时ZnT8A、GADA和IA-2A的检出率分别为35.6%(48/135),57.0%(77/135)和23.7%(32/135),三抗体联合检测总阳性率为70.4%(95/135)。病程2年的患者ZnT8A和IA-2A的滴度分别在发病后第15、18个月内下降了42.2%和44.8%,变化显著(P0.05);GADA则无显著变化(P>0.05)。75例T1DM患者病程5-10年后,ZnT8A和IA-2A的水平下降了48.2%和54.1%,变化显著(P值均0.05)。结论ZnT8A和IA-2A水平在T1DM发病早期尤其是发病后18个月内随病程延长而显著降低,GADA则不随病程变化。

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